The potency of topical steroids is determined by the amount of vasoconstriction (narrowing of the blood vessels) they produce. All topical steroid therapies, including corticosteroids, have been shown to result in vasoconstriction. It has been suggested that topical steroids may increase the vascular permeability of the skin, which could compromise the wound healing process (18), vasoconstriction steroids do cause. Because of the high systemic concentration of the active drug, the steroid will be retained in the skin and in the blood for a relatively long time after administration, making it difficult to discontinue the therapy without adverse effects. These clinical implications have been discussed in detail elsewhere (9), do steroids bother your stomach.For this study, we conducted a prospective study to examine the effects of an intravenous bolus (0.75 mg/kg) of topical dexamethasone/acute steroid, dexamethasone/diclofenac, or dexamethasone/diclofenac on chronic wound healing, in a randomized controlled trial to determine the effects of each drug on time to heal, number of new blood vessels, and new platelets.SUBJECTS AND METHODSStudy designThis study was a multicenter, single-center study with a design to measure improvement in wound healing in the field compared with the study-specific design. The study protocol was approved by the institutional review boards at all sites.PatientsPatients were screened with the clinical questionnaire (Table 1) and were enrolled using either a random-effects, open-label, or fixed-effects, dose-response study design, do steroids burn calories. In this design, the baseline outcome measure was the incidence of infections during follow-up. The primary outcome was time to healing, do steroids help burn fat. Inclusion criteria were any wound pain, a length of illness ≥2 months, and a mean or minimum of 30 days of treatment, do steroids increase height. Exclusion criteria were any major infection, cancer, pregnancy, the use of an intravenous catheter, corticosteroid therapy, the use of an alternative therapy, alcohol/tobacco use, pregnancy, or use of oral corticosteroids. Patients were also excluded from consideration for this study if they had previously received systemic steroids and had an increased rate of wound healing after systemic steroid administration (defined as greater than or equal to 3 years). The use of systemic steroids, steroids obtained by noninjectable methods, or corticosteroids obtained by injection was avoided, do steroids cause vasoconstriction.Conducting the study
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